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KMID : 0882420020620010083
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Korean Journal of Medicine
2002 Volume.62 No. 1 p.83 ~ p.89
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Docetaxel and cisplatin combination chemotherapy for advanced gastric cancer failed to 5-fluorouracil-based chemotherapy
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Lee Hyo-Rak
Park Se-Hoon
Song Seo-Young
Park Joon-Oh
Lee Sun-Il
Kim Ki-Hyun
Kim Won-Seog
Jung Chul-Won
Im Young-Hyuck
Lee Hong-Ghi
Park Keun-Chil
Park Chan-Hyung
Kang Won-Ki
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Abstract
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Background: There is no effective treatment in patients with advanced gastric cancer failed to first-line chemotherapy. Taxane is one of new drugs identified as having substantial activity in gastric cancer. We performed a phase II trial to evaluate the efficacy and toxicity of docetaxel plus cisplatin regimen as a salvage chemotherapy for advanced gastric cancer failed to 5-fluorouracil (5-FU)-based chemotherapy.
Methods: Metastatic or recurrent gastric cancer patients failed to 5-FU-based regimen with an Eastern Cooperative Oncology Group (ECOG) performance score ≤ 2 were eligible in this trial. Docetaxel (60 ㎎/㎡) was infused over 1 hour, before cisplatin (60 ㎎/㎡) infused over 2 hours on day 1, once every 3 weeks until disease progression or unacceptable toxicity was detected. Response to treatment was assessed every two or three cycles.
Results: From October 1999 to December 2000, forty-one patients were enrolled in this study. Twenty-eight of forty-one patients were assessable for response. Partial response was observed in seven patients and stable disease in four patients. The response rate was 25.0% (95% confidence interval: 20.4∼29.6%) and median duration of response was 22 weeks (range: 11∼53 weeks). The median survival of all enrolled patients was 24 weeks (range: 7∼65 weeks). For a total of 112 cycles of chemotherapy, grade 3 and 4 toxicity was 8.9% for neutropenia, 4.5% for nausea/vomiting and 1.8% for mucositis.
Conclusion: Salvage chemotherapy with docetaxel plus cisplatin regimen in gastric cancer was active with acceptable toxicities.
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KEYWORD
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Stomach neoplasm, Docetaxel, Cisplatin
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